2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N18193
    Prunasinamide
    Prunasinamide is a catabolite of Prunasin (HY-N1548) and can be found in senescent leaves of Prunus laurocerasus. Prunasinamide can be generated from Prunasin via the Radziszewski reaction.
    Prunasinamide
  • HY-W020576
    Rivastigmine metabolite
    		99.01%
    Rivastigmine metabolite (NAP 226-90) is a metabolite produced by the hydrolysis of Rivastigmine (HY-17368). Rivastigmine metabolite serves as a surrogate marker to track the bioavailability, metabolic extent, and transdermal patch delivery rate of Rivastigmine.
    Rivastigmine metabolite
  • HY-131269
    Febuxostat impurity 7
    		98.18%
    Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 7
  • HY-135388
    ent-Ezetimibe
    ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    ent-Ezetimibe
  • HY-19570A
    NSC 15830 hydrochloride
    NSC 15830 (S-(1,2-Dichlorovinyl)-L-cysteine) hydrochloride is a nephrotoxin and metabolite of trichloroethylene. NSC 15830 hydrochloride inhibits pathogen-stimulated TNF-α.
    NSC 15830 hydrochloride
  • HY-135372
    Descarbamoyl cefuroxime
    Descarbamoyl cefuroxime is a degradation product of Cefuroxime. Descarbamoyl cefuroxime is also an intermediate for the synthesis of Cephalosporin antibiotics.
    Descarbamoyl cefuroxime
  • HY-156803
    Estradiol 3,4-quinone
    Estradiol 3,4-quinone (E2-3,4-Q) is a metabolite of Estradiol (HY-B0141). Estradiol 3,4-quinone is a highly electrophilic compound and can induce cancer initiating mutations.
    Estradiol 3,4-quinone
  • HY-W711177
    Mono(7-carboxy-2-methyloctyl) phthalate-d4
    Mono(7-carboxy-2-methyloctyl) phthalate-d4 (MCNP-d4) is the deuterium labeled Mono(7-carboxy-2-methyloctyl) phthalate (HY-133679). Mono(7-carboxy-2-methyloctyl) phthalate (MCNP) is a metabolite of Di-decyl phthalate (DDP).
    Mono(7-carboxy-2-methyloctyl) phthalate-d<sub>4</sub>
  • HY-G0003S1
    Iloperidone metabolite Hydroxy Iloperidone-d3
    Iloperidone metabolite Hydroxy Iloperidone-d3 is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone (HY-G0003). Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia.
    Iloperidone metabolite Hydroxy Iloperidone-d<sub>3</sub>
  • HY-186206
    (Rac)-EGC-M7
    (Rac)-EGC-M7 is a racemic microbial metabolite of green tea Catechin (EGC) (HY-N0898), and acts as an inhibitor of nitric oxide production and cancer cell growth. (Rac)-EGC-M7 can be used in the research of esophageal squamous cell carcinoma and colon adenocarcinoma.
    (Rac)-EGC-M7
  • HY-N17728
    11βh,13-Dihydroparthenolide
    11βh,13-Dihydroparthenolide (Compound 314) is a metabolite of Parthenolide (HY-N0141), which can be produced by biotransformation of filamentous fungi.
    11βh,13-Dihydroparthenolide
  • HY-114658R
    Daunomycinone (Standard)
    Daunomycinone (Standard) is the analytical standard of Daunomycinone (HY-114658). This product is intended for research and analytical applications. Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia.
    Daunomycinone (Standard)
  • HY-W740123
    8-Hydroxy mianserin
    8-Hydroxy mianserin is a synthetic metabolite of Mianserin (HY-B0188). 8-Hydroxy mianserin serves as a precursor for the chemical synthesis of mianserin metabolite derivatives.
    8-Hydroxy mianserin
  • HY-121899
    1-Oxo Ibuprofen
    1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Oxo Ibuprofen
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-W003467S1
    Rabeprazole sulfide-d3
    Rabeprazole sulfide-d3 is the deuterium labeled Rabeprazole Sulfide (HY-W003467). Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection.
    Rabeprazole sulfide-d<sub>3</sub>
  • HY-123144
    N-Hydroxymethylsorafenib
    N-Hydroxymethylsorafenib is a Sorafenib (HY-10201) metabolite, and can be used for research of metabolite of Sorafenib.
    N-Hydroxymethylsorafenib
  • HY-N0873A
    Iso-Sagittatoside A
    Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma.
    Iso-Sagittatoside A
  • HY-143975S
    Loxapine impurity 2-d8
    Loxapine impurity 2-d8 is the deuterium labeled Loxapine impurity 2.
    Loxapine impurity 2-d<sub>8</sub>
  • HY-117580S2
    16α-Hydroxyprednisolone-d5
    16α-Hydroxyprednisolone-d5 (OH-PRED-d5) is the deuterium labeled 16α-Hydroxyprednisolone (HY-117580). 16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily.
    16α-Hydroxyprednisolone-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity